Anti-Human ERCC1 Monoclonal Antibody

ERCC1单克隆抗体

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
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基本信息

数据文档 查看数据文档
货号 MA01787
规格 100μl
宿主 Mouse
免疫原 Synthetic Peptide
特异性
亚型 IgG
反应性 Human
克隆 8K5
Uniprot P07992
浓度 1mg/mL
推荐稀释度 WB 1:1000-1:2000
配方
应用范围 WB
别名 COFS 4,COFS4,DNA excision repair protein ERCC 1,DNA excision repair protein ERCC-1,DNA excision repair protein ERCC1,ERCC 1,ERCC1,ERCC1,Excision repair cross complementation group 1,Excision repair cross complementing 1,Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1,Excision repair protein,RAD 10,RAD10,UV 20,UV20
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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