NR2F6 belongs to NR2F subfamily members,which have their roles in the regulation of neurogenesis,organogenesis,and cellular differentiation during embryonic development . NR2F6 acts as transcription factor by binding to a TGACCT direct-repeat motif and has been established in controlling facets of central nervous system (CNS) [12690040]. It is a nuclear attenuator that directly interferes with DNA binding of NF-AT and,subsequently,transcriptional activity of the NF-AT-dependent IL-17 expression. Otherwise,NR2F6 negatively interfered with transcriptional cytokine responses and acted as a barrier against autoimmunity .