The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II.CHML (CHM Like, Rab Escort Protein 2) is a Protein Coding gene. Diseases associated with CHML include Choroideremia. Among its related pathways are Vesicle-mediated transport and RAB geranylgeranylation. GO annotations related to this gene include GTPase activator activity and Rab geranylgeranyltransferase activity. An important paralog of this gene is CHM.