Anti-Human CD209 Polyclonal Antibody

CD209多克隆抗体

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
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基本信息

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货号 PA03449
规格 100μl
宿主 Rabbit
免疫原 Synthetic peptide of human CD209
特异性 Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.
亚型 IgG
反应性 Human
克隆
Uniprot Q9NNX6
浓度 1 mg/mL
推荐稀释度 WB 1:500-1:1000
配方
应用范围 WB
别名 C type lectin domain family 4 member L,C-type lectin domain family 4 member L,CD 209,CD209,CD209 antigen,CD209 antigen-like protein A,CD209 molecule,CD209,Cd209a,CDSIGN,CIRE,CLEC4L,DC SIGN,DC SIGN1,DC-SIGN,DC-SIGN1,DCSIGN,Dendritic cell specific ICAM 3 grabbing nonintegrin 1,Dendritic cell specific ICAM3 grabbing nonintegrin 1,Dendritic cell-specific ICAM-3-grabbing non-integrin 1,Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin,Dengue fever,protection against,included,Dentritic Cell Specific ICAM3 Grabbing Nonintegrin,HIV GP120 Binding Protein,MGC129965,MGC130443,SIGN-R1,SIGNR5
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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