The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene.SIRPB1 (Signal Regulatory Protein Beta 1) is a Protein Coding gene. Diseases associated with SIRPB1 include Composite Lymphoma. Among its related pathways are Cell junction organization and Innate Immune System. An important paralog of this gene is SIRPA.