BRD8 is one of the bromodomain-containing proteins,which is an acetylated lysine- binding domain and thought to be involved in regulation of protein acetylation and/or HAT (histone acetyl transferase) activity . It is also reported to be an accessory subunit of NuA4 HAT complex (also known as TRRAP/TIP60 complex) through biochemical purification . In addition,it can bind to thyroid hormone receptor-ß and/or retinoid X receptor,and can act as a coactivator of the nuclear hormone receptor-mediated transcription in reporter assays .