The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.BIK (BCL2 Interacting Killer) is a Protein Coding gene. Diseases associated with BIK include Apple Allergy and Wolfram Syndrome 2. Among its related pathways are Apoptosis and Autophagy and Apoptosis Modulation and Signaling. GO annotations related to this gene include protein heterodimerization activity and BH domain binding.