Zinc-alpha-2-glycoprotein (AZGP1) is a 41-kDa soluble protein normally found in body fluids,functions as a lipid mobilizing factor . It is known to be expressed in the secretory epithelia of the liver,lung,breast,GI tract and sweat glands,sharing significant structural similarity with the class I major histocompatibility complex (MHC) antigens . AZGP1 is involved in carcinogenesis and differentiation. Altered expression of AZGP1 has been reported in breast cancer,prostate cancer and lung adenocarcinoma,hepatocellular carcinoma,pancreatic carcinoma and oral tumors .