Annexin A3 (Anxa3),also named as lipocortin3,placental anticoagulant protein3 (PAP-III),belongs to annexin family. Annexins are calcium-dependent phospholipids-binding high-abundant intracellular proteins. ANXA3 has been reported to play crucial roles in a diverse range of molecular and cellular processes,including ion channel regulation,anticoagulation,anti-inflammation,vesicle traffick-ing,signal transduction,cell migration,and cell proliferation. It also exhibits important roles in cancer progression,metastasis,and drug resistance.