Recombinant Mouse IL12RB2 / IL12R-beta 2 Protein (His tag)

Interleukin-12 receptor subunit beta-2 (IL12RB2), also known as IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, and IL-12RB2, is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. IL12RB2 belongs to the type I cytokine receptor family. The coexpression of IL12RB2 and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of IL12RB2 is up-regulated by IFN gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of IL12RB2 is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. IL12RB2 promotes the proliferation of T-cells as well as NK cells. IL12RB2 induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
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基本信息

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货号 TP07971
规格 20ug,50ug,100ug…
宿主 HEK293 Cells
Accession NP_032380.1
分子大小 70 kDa
AP_Mol_Weight 120-130 kDa
Tag C-His
蛋白序列 Met 1-Asn 637
纯度 > 95% by HPLC
浓度
配方 PBS
别名 A930027I18Rik;Ifnm;IL-12RB2
生物学活性 Measured by its ability to bind Mouse IL12A & IL12B Heterodimer Protein in a functional ELISA.Immobilized mouse IL12RB2-His at 10 µg/ml (100 μl/well) can bind Mouse IL12A & IL12B Heterodimer Protein. The EC50 of Mouse IL12A & IL12B Heterodimer Protein is
保存条件 4°C 短期保存 (1-2 周). 长期保存在 -20°C or -70°C. 避免反复冻融.
注意 仅用于科学研究, 不能用于疾病诊断.

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