Recombinant Mouse Bone Morphogenetic Protein Receptor Type IA/Activin Receptor-like Kinase 3 Protein

ALK-3 is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. The BMP receptors consists of the type I receptors BMPR1A and BMPR1B and the type I I receptor BMPR2. Seven known type I serine/threonine kinases and five mammalian type II serine/threonine kinase receptors function in TGF-beta superfamily signal transduction. The downstream molecules of the type I BMP receptors include the Smad (Smad1, 5 and 8) proteins that are phosphorylated in a ligand-dependent manner, and relay the BMP signal from the receptors to target genes in the nucleus. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. ALK-3 contains a GS domain and a protein kinase domain. ALK-3 is widely expressed. Defects in BMPR1A gene are a cause of a significant proportion of cases of Juvenile polyposis syndrome (JPS).
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基本信息

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货号 TP04642
规格 20ug,50ug,100ug…
宿主 Human Cells
Accession P36895
分子大小 42.2 kDa
AP_Mol_Weight 55-60&120 kDa
Tag C-Fc-6His
蛋白序列 Gln24-Arg152
纯度 > 95% by HPLC
浓度
配方 PBS
别名 ALK-3;Bone morphogenetic protein receptor type-1A;BMP type-1A receptor;BMPR-1A;Activin receptor-like kinase 3;BMP-2/BMP-4 receptor;Serine/threonine-protein kinase receptor R5;SKR5;CD292;;Acvrlk3
生物学活性 Measured by its ability to inhibit recombinant human BMP4 induced activity in MC3T3-E1 Mouse osteoblastic cells. The ED50 for this effect is typically 0.5-2 µg/ml in the presence of 50 ng/ml of recombinant human BMP4.
保存条件 4°C 短期保存 (1-2 周). 长期保存在 -20°C or -70°C. 避免反复冻融.
注意 仅用于科学研究, 不能用于疾病诊断.

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