Recombinant Human Frizzled-6 / FZD6 Protein (Fc tag)

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.
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基本信息

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货号 TP06780
规格 20ug,50ug,100ug…
宿主 HEK293 Cells
Accession NP_003497.2
分子大小 42 kDa
AP_Mol_Weight
Tag C-Fc
蛋白序列 Met 1-Val153
纯度 > 95% by HPLC
浓度
配方 PBS
别名 FZ-6;FZ6;HFZ6;NDNC10
生物学活性
保存条件 4°C 短期保存 (1-2 周). 长期保存在 -20°C or -70°C. 避免反复冻融.
注意 仅用于科学研究, 不能用于疾病诊断.

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