BIP Monoclonal Antibody (Clone AT3D2)

Binding immunoglobulin protein (BIP) also known as 78kDa glucose-regulated protein(GRP-78) or heat shock 70kDa protein 5(HSPA5) is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum(ER) that binds newly synthesized proteins as they are translocated into the ER, and maintains them in a state competent for subsequent folding and oligomerization. BIP is also an essential component of the translocation machinery, as well as playing a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. BIP is an abundant protein under all growth conditions, but its synthesis is markedly induced under conditions that lead to the accumulation of unfolded polypeptides in the ER.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA01116
Size 100 µL
Host Type Mouse
Immunogen Recombinant human BIP (20-650aa) purified from Baculo virus.
Specificity
Isotype IgG1,k
Reacitivity Human
Clone Anti-human BIP mAb, clone AT3D2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human BIP protein.
Uniprot
Concentration 1 mg/mL
Dilution
Formulation Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.
Application ELISA, WB, Flow cytometry, ICC/IF
Other Names Binding immunoglobulin protein, HSPA5, heat shock 70kDa protein 5, GRP78, glucose-regulated protein 78kD, MIF2.
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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