APP770 (351) Anti-Human Rabbit IgG Affinity Purify

Alzheimer's disease (AD) is a typical senile dementia and it is believed that accumulation of Amyloidβ (Aβ) in brain parenchyma is a major cause of the disease. Meanwhile, accumulation of Aβ has been also observed on cerebrovascular walls of nearly 90% of individuals suffering with AD. Aβ is known to be produced from Amyloid Precursor Protein (APP) by cleavage with two types of protease (β- and γ- secretase) and Aβ molecules which accumulate in brain parenchyma are mainly produced from APP expressed in neurons, APP695. In contrast to this, another different APP, APP770, was found to be expressed in cerebrovascular endothelial cells, and it has been newly reported that the Aβ produced from the APP770 can accumulate on cerebrovascular walls (ref. 1). This antibody recognizes human APP770.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01062
Size 100 μg
Host Type Rabbit
Immunogen Synthetic peptide of a part of human APP770.
Specificity
Isotype
Reacitivity Human
Clone
Uniprot
Concentration
Dilution
Formulation Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3.
Application IHC, Immunofluorescence, WB.
Other Names
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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