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Anti-Mouse Phospho-FADD (Ser191) Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01845
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human FADD around the phosphorylation site of Ser191
Specificity Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Isotype IgG
Reacitivity Mouse
Clone
Uniprot Q13158
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
Formulation
Application WB,IHC-p,ELISA
Other Names FADD,FADD protein,FADD,Fas (TNFRSF6) associated via death domain,Fas associated via death domain,Fas associating death domain containing protein,Fas associating protein,Fas associating protein with death domain,Fas TNFRSF6 associated via death domain,FAS-associated death domain protein,FAS-associating death domain-containing protein,GIG 3,GIG3,Growth inhibiting gene 3 protein,Growth-inhibiting gene 3 protein,H sapiens mRNA for mediator of receptor induced toxicity,Mediator of receptor induced toxicity,MGC8528,MORT 1,MORT1,Protein FADD
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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