Anti-Human TPSB2 Polyclonal Antibody

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. 
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Properties

Data Sheet Click for Datasheet
Catalog Number PA07562
Size 100μl
Host Type Rabbit
Immunogen Full length fusion protein
Specificity
Isotype IgG
Reacitivity Human
Clone
Uniprot P20231
Concentration 0.3 mg/mL
Dilution IHC 1:25-100, ELISA 1:2000-5000
Formulation
Application IHC,ELISA
Other Names TPS2,tryptaseB,tryptaseC
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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