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Anti-Human TFF1 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. 
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Properties

Data Sheet Click for Datasheet
Catalog Number PA04799
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide from human protein
Specificity Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level).
Isotype IgG
Reacitivity Human
Clone
Uniprot P04155
Concentration 1mg/mL
Dilution IHC 1:50-200, ELISA 1:10000-20000
Formulation
Application IHC-p,ELISA
Other Names BCEI,Breast cancer estrogen inducible protein,Breast cancer estrogen inducible sequence,Breast cancer estrogen-inducible protein,D21S21,Gastrointestinal trefoil protein,Gastrointestinal trefoil protein pS2,hP1.A,HP1A,HPS 2,HPS2,pNR 2,PNR-2,pNR2,Polypeptide P1.A,Protein pS2,PS 2,pS2,pS2 protein,TFF 1,TFF1,TFF1,Trefoil factor 1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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