Anti-Human SSX1 Polyclonal Antibody

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. SSX1 (SSX Family Member 1) is a Protein Coding gene. Diseases associated with SSX1 include Sarcoma, Synovial and Sarcoma. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include nucleic acid binding and transcription corepressor activity. An important paralog of this gene is SSX7.