Anti-Human SRY Polyclonal Antibody

This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.SRY (Sex Determining Region Y) is a Protein Coding gene. Diseases associated with SRY include 46Xy Sex Reversal 1 and 46Xx Sex Reversal 1. Among its related pathways are CCR5 Pathway in Macrophages and Signaling by Wnt. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is SOX3.