Anti-Human/Rat SH2B2 Polyclonal Antibody

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA09466
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human SH2B2
Specificity Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines.
Isotype IgG
Reacitivity Human,Rat
Clone
Uniprot O14492
Concentration 0.3 mg/mL
Dilution IHC 1:25-1:100
Formulation
Application IHC,ELISA
Other Names APS
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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