Anti-Human/Rat IkB alpha Polyclonal Antibody

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA04192
Size 100μl
Host Type Rabbit
Immunogen Recombinant Protein
Specificity
Isotype IgG
Reacitivity Human,Rat
Clone
Uniprot P25963
Concentration 1mg/mL
Dilution WB 1:2000-5000, IHC 1:200-500
Formulation
Application WB,IHC-p
Other Names I kappa B alpha,I-kappa-B-alpha,IkappaBalpha,IkB-alpha,IKBA,IKBA,IKBalpha,MAD 3,MAD3,Major histocompatibility complex enhancer-binding protein MAD3,NF kappa B inhibitor alpha,NF-kappa-B inhibitor alpha,NFKBI,NFKBIA,Nuclear factor of kappa light chain gene enhancer in B cells,Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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