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Anti-Human Phospho-P63 (Ser455) Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01804
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human p63 around the phosphorylation site of Ser455
Specificity Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.
Isotype IgG
Reacitivity Human
Clone
Uniprot Q9H3D4
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
Formulation
Application WB,IHC-p,ELISA
Other Names AIS,Amplified in squamous cell carcinoma,B(p51A),B(p51B),Chronic ulcerative stomatitis protein,CUSP,DN p63 alpha 1,DNp63,EEC3,id:ibd3516,Keratinocyte transcription factor,Keratinocyte transcription factor KET,KET,LMS,MGC115972,MGC192897,NBP,OFC8,OTTHUMP00000209732,OTTHUMP00000209733,OTTHUMP00000209734,OTTHUMP00000209735,OTTHUMP00000209737,OTTHUMP00000209738,OTTHUMP00000209739,OTTHUMP00000209740,OTTHUMP00000209741,OTTHUMP00000209742,OTTHUMP00000209743,OTTHUMP00000209744,p40,p51,P51/P63,p53-related protein p63,p53CP,p63,P63,p73H,p73L,RHS,SHFM4,TAp63alpha,TP53CP,TP53L,TP63,TP73L,Transformation related protein 63,Transformation-related protein 63,Trp53rp1,Trp63,Tumor protein 63,Tumor protein p53-competing protein,Tumor protein p53-like,Tumor protein p63,Tumor protein p63 deltaN isoform delta,Tumor protein p73,Tumor protein p73-like
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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