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Anti-Human PDE4A Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA08515
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human PDE4A
Specificity Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level).
Isotype IgG
Reacitivity Human
Clone
Uniprot P27815
Concentration 0.5 mg/mL
Dilution WB 1:500-1:2000, IHC 1:50-1:200
Formulation
Application WB,IHC,ELISA
Other Names 5''-cyclic phosphodiesterase 4A,cAMP specific phosphodiesterase,cAMP-specific 3'',cAMP-specific 3',5'-cyclic phosphodiesterase 4A,DPDE2,dunce like phosphodiesterase E2,PDE 4A,PDE4,PDE46,PDE4A,PDE4A,PDE4A11,Phosphodiesterase 4A,phosphodiesterase 4A cAMP specific,Phosphodiesterase 4A,cAMP-specific (dunce,phosphodiesterase E2 dunce homolog,Phosphodiesterase E2 dunce homolog,Drosophila,phosphodiesterase isozyme 4,phosphodiesterase type 4A11
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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