Anti-Human PCLAF Polyclonal Antibody

PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA02022
Size 100μl
Host Type Rabbit
Immunogen Recombinant human KIAA0101 protein
Specificity Expressed predominantly in liver, pancreas and placenta. Not detected in heart or brain. Highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas, adrenocortical carcinomas, and in non-small-cell lung cancer lines.
Isotype IgG
Reacitivity Human
Clone
Uniprot Q15004 
Concentration 2 mg/mL
Dilution WB 1:500-1:1000,IHC 1:50-1:100
Formulation
Application WB
Other Names L5,NS5 ATP9,NS5ATP9,OEATC 1,OEATC,OEATC-1,OEATC1,p15(PAF),p15PAF,PAF,PAF,PCNA associated factor,PCNA-associated factor,
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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