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Anti-Human NANOS1 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
NANOS1 (Nanos C2HC-Type Zinc Finger 1) is a Protein Coding gene. Diseases associated with NANOS1 include Spermatogenic Failure 12. GO annotations related to this gene include RNA binding and translation repressor activity. An important paralog of this gene is NANOS3.This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA04503
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from Nanos Homologue 1 (NANOS1)
Specificity Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness.
Isotype IgG
Reacitivity Human
Clone
Uniprot Q8WY41
Concentration 1mg/mL
Dilution WB 1:500-2000, ELISA 1:10000-20000
Formulation
Application WB,IHC-p,ELISA
Other Names EC Rep1a,EC_Rep1a,NANO1,NANOS 1,Nanos homolog 1 (Drosophila),Nanos homolog 1,NANOS1,Nos 1,NOS-1,Nos1,OTTHUMP00000046853,Rep 1a,Rep1a
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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