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Anti-Human /Mouse TCL1 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).
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Properties

Data Sheet Click for Datasheet
Catalog Number PA02990
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human TCL1A
Specificity Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
Isotype IgG
Reacitivity Human ,Mouse
Clone
Uniprot P56279
Concentration 0.4 mg/mL
Dilution WB 1:500-1:2000
Formulation
Application WB
Other Names Anti TCL1A,Lymphoma/leukemia,T-cell,Oncogene TCL-1,Oncogene TCL1,P14 TCL1,P14 TCL1 protein,Protein p14 TCL1,T cell leukemia 1,T cell lymphoma 1,T cell lymphoma 1A,T-cell leukemia/lymphoma 1A,T-cell leukemia/lymphoma protein 1A,TCL 1 protein,TCL1,TCL1 oncogene,TCL1 PEN,Tcl1a,TCL1A,TCL1A
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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