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Anti-Human/Mouse TCF7 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA05992
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the N-terminal region of human TCF-1
Specificity Predominantly in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.
Isotype IgG
Reacitivity Human,Mouse
Clone
Uniprot P36402
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Formulation
Application WB,IHC-p,ELISA
Other Names FLJ36364,MGC47735,OTTHUMP00000159391,T cell factor 1,T cell specific transcription factor 1,T-cell factor 1,T-cell-specific transcription factor 1,TCF-1,TCF-7,TCF1,Tcf7,TCF7 transcription factor 7,TCF7,Transcription factor 7 (T cell specific HMG box),Transcription factor 7,Transcription factor-7,T-cell specific,Transcription factor-7,T-cell specific,1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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