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Anti-Human/Mouse TAB3 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. 
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Properties

Data Sheet Click for Datasheet
Catalog Number PA11922
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human TAB3
Specificity Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.
Isotype IgG
Reacitivity Human,Mouse
Clone
Uniprot Q8N5C8
Concentration 0.2 mg/mL
Dilution WB 1:200-1:1000, IHC 1:50-1:200
Formulation
Application WB,IHC,ELISA
Other Names MAP3K7IP 3,Mitogen-activated protein kinase kinase kinase 7-interacting protein 3,NAP1,NF-kappa-B-activating protein 1,NFkB activating protein 1,TAB-3,Tab3,TAB3,TAK1 binding protein 3,TAK1-binding protein 3,TGF-beta-activated kinase 1 and MAP3K7-binding protein 3,TGF-beta-activated kinase 1-binding protein 3
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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