Anti-Human/Mouse SWAP70 Polyclonal Antibody

Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
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Properties

Data Sheet Click for Datasheet
Catalog Number PA07478
Size 100μl
Host Type Rabbit
Immunogen Fusion protein of human SWAP70
Specificity Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).
Isotype IgG
Reacitivity Human,Mouse
Clone
Uniprot Q9UH65
Concentration 0.2 mg/mL
Dilution IHC 1:25-100, ELISA 1:2000-5000
Formulation
Application IHC,ELISA
Other Names KIAA0640,70kDa,AV235546,FLJ39540,HSPC321,SWA 70 protein,SWAP 70,SWAP switching B-cell complex 70kDa subunit,SWAP-70,SWAP70,Switch associated protein 70,Switch-associated protein 70,SWP70
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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