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Anti-Human/Mouse SRGAP1 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 ultimately leads to a decrease in actin polymerization.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA11178
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human SRGAP1
Specificity Expressed in brain, lung, kidney, and testis.
Isotype IgG
Reacitivity Human,Mouse
Clone
Uniprot Q7Z6B7
Concentration 0.4 mg/mL
Dilution WB 1:500-1:2000, IHC 1:25-1:100
Formulation
Application WB,IHC,ELISA
Other Names 4930572H05Rik,ARHGAP13,FLJ22166,KIAA1304,RGD1566260,Rho GTPase activating protein 13,Rho GTPase-activating protein 13,SLIT ROBO Rho GTPase activating protein 1,SLIT-ROBO Rho GTPase-activating protein 1,SRGAP 1,srGAP1,SRGP1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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