Anti-Human/Mouse/Rat TSN Polyclonal Antibody

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants.TSN (Translin) is a Protein Coding gene. Diseases associated with TSN include Liposarcoma. Among its related pathways are Gene Expression and Mitotic Prophase. GO annotations related to this gene include sequence-specific DNA binding and protein complex binding.