Anti-Human/Mouse/Rat TSC22D3 Polyclonal Antibody

The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene. 
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Properties

Data Sheet Click for Datasheet
Catalog Number PA12058
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human TSC22D3
Specificity Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot Q99576
Concentration 0.6 mg/mL
Dilution IHC 1:50-1:200
Formulation
Application IHC,ELISA
Other Names Delta sleep-inducing peptide immunoreactor,DIP,DSIP immunoreactive leucine zipper protein,DSIP-immunoreactive peptide,Dsip1,Dsipi,GILZ,Glucocorticoid-induced leucine zipper protein,hDIP,Protein DIP,T22D3,TSC-22-like protein,TSC-22-related protein,TSC-22R,TSC22 domain family protein 3,TSC22 domain family,member 3,TSC22 related inducible leucine zipper 3,TSC22D3
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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