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Anti-Human/Mouse/Rat TRPM1 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA11256
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human TRPM1
Specificity Expressed in the retina where it localizes to the outer plexiform layer. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot Q7Z4N2
Concentration 0.3 mg/mL
Dilution IHC 1:25-1:100
Formulation
Application IHC,ELISA
Other Names CSNB1C,Long transient receptor potential channel 1,LTrpC1,Melastatin 1,Melastatin-1,MLSN1,Transient receptor potential cation channel subfamily M member 1,Transient receptor potential cation channel,subfamily M,member 1,Transient receptor potential melastatin family,TRPM1,TRPM1 protein,TRPM1,Weakly similar to F54D1.5 [C.elegans]
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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