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Anti-Human/Mouse/Rat SMAD7 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA10757
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human SMAD7
Specificity Ubiquitous with higher expression in the lung and vascular endothelium.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot O15105
Concentration 0.4 mg/mL
Dilution IHC 1:50-1:200
Formulation
Application IHC,ELISA
Other Names CRCS3,FLJ16482,hSMAD 7,hSMAD7,MAD (mothers against decapentaplegic Drosophila) homolog 7,MAD,Mad homolog 7,MAD homolog 8,MAD mothers against decapentaplegic homolog 7,MADH 7,MADH 8,MADH6,MADH8,Mothers Against Decapentaplegic Drosophila Homolog of 6,Mothers Against Decapentaplegic Drosophila Homolog of 7,Mothers against decapentaplegic homolog 7,Mothers against decapentaplegic homolog 8,Mothers against DPP homolog 7,Mothers against DPP homolog 8,SMA- AND MAD-RELATED PROTEIN 7,SMAD 7,SMAD,SMAD family member 7,SMAD,mothers against DPP homolog 7 (Drosophila),SMAD,mothers against DPP homolog 7,SMAD6,Smad7,SMAD7
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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