Anti-Human/Mouse/Rat SCN5A Polyclonal Antibody

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA10226
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human SCN5A
Specificity Found in jejunal circular smooth muscle cells (at protein level). Expressed in human atrial and ventricular cardiac muscle but not in adult skeletal muscle, brain, myometrium, liver, or spleen. Isoform 4 is expressed in brain.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot Q14524
Concentration 0.2 mg/mL
Dilution IHC 1:25-1:100
Formulation
Application IHC,ELISA
Other Names Cardiac tetrodotoxin insensitive voltage dependent sodium channel alpha subunit,CDCD2,CMD1E,CMPD2,HB1,HB2,HBBD,HH1,ICCD,IVF,LQT3,PFHB1,Scn5a (gene name),Scn5a,SCN5A,Sodium channel protein cardiac muscle alpha subunit,Sodium channel protein cardiac muscle subunit alpha,Sodium channel protein type 5 subunit alpha,Sodium channel protein type V alpha subunit,Sodium channel protein type V subunit alpha,SSS1,VF1,Voltage gated sodium channel alpha subunit Nav1.5,Voltage-gated sodium channel subunit alpha Nav1.5
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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