Anti-Human /Mouse /Rat RPS6KA5 Polyclonal Antibody

Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
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Properties

Data Sheet Click for Datasheet
Catalog Number PA03348
Size 100μl
Host Type Rabbit
Immunogen Synthetic peptide of human RPS6KA5 (Ab-376)
Specificity Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.
Isotype IgG
Reacitivity Human ,Mouse ,Rat
Clone
Uniprot O75582
Concentration 1 mg/mL
Dilution WB 1:500-1:2000
Formulation
Application WB
Other Names 90 kDa ribosomal protein S6 kinase 5,EC 2.7.11.1,KS6A5,MGC1911,Mitogen and stress activated protein kinase 1,MSPK1,Nuclear Mitogen And Stress Activated Protein Kinase 1,Nuclear mitogen- and stress-activated protein kinase 1,Ribosomal protein S6 kinase 90kD polypeptide 5,Ribosomal protein S6 kinase 90kDa,Ribosomal protein S6 kinase 90kDa polypeptide 5,Ribosomal Protein S6 Kinase Alpha 5,Ribosomal protein S6 kinase alpha-5,RLPK,RPS6KA5,RSK Like Protein Kinase,RSK-like protein kinase,RSKL,S6K alpha 5,S6K-alpha-5
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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