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Anti-Human/Mouse/Rat RFFL Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA11776
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human RFFL
Specificity Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot Q8WZ73
Concentration 0.3 mg/mL
Dilution IHC 1:25-1:100
Formulation
Application IHC,ELISA
Other Names CARP-2,CARP2,Caspase regulator CARP2,Caspases 8 and 10 associated RING finger protein 2,caspases-8 and -10- associated RING finger protein 2,Caspases-8 and -10-associated RING finger protein 2,E3 ubiquitin protein ligase rififylin,E3 ubiquitin-protein ligase rififylin,Fring,FYVE RING finger protein Sakura,FYVE-RING finger protein Sakura,Rffl,RFFL,Rififylin,RING finger and FYVE like domain containing protein,RING finger and FYVE-like domain-containing protein 1,RING finger protein 189,RING finger protein 34 like,RING finger protein 34-like,RNF189,RNF34L
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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