Anti-Human/Mouse/Rat PYCARD Polyclonal Antibody

Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA02150
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the N-terminal region of human ASC
Specificity Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and Molt 4 lymphocytic leukemia cells.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot Q9ULZ3
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
Formulation
Application WB,IHC-p,IF,ELISA
Other Names Apoptosis associated speck like protein containing a CARD,Apoptosis-associated speck-like protein containing a CARD,ASC,ASC,CARD 5,CARD5,Caspase recruitment domain containing protein 5,Caspase recruitment domain protein 5,Caspase recruitment domain-containing protein 5,hASC,MGC10332,PYCARD,PYD and CARD domain containing,PYD and CARD domain containing protein,PYD and CARD domain-containing protein,Target of methylation induced silencing 1,Target of methylation-induced silencing 1,TMS 1,TMS,TMS1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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