Anti-Human/Mouse/Rat Phospho-GRK2 (Ser685) Polyclonal Antibody

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01709
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human GRK 2 around the phosphorylation site of Ser685
Specificity Expressed in peripheral blood leukocytes.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot P25098
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:5000
Formulation
Application WB,ELISA
Other Names ADRBK1,Adrenergic beta receptor kinase 1,ARBK1,BARK,BARK1,Beta adrenergic receptor kinase 1,Beta ARK 1,Beta ARK1,Beta-adrenergic receptor kinase 1,Beta-ARK-1,FLJ16718,G protein coupled receptor kinase 2,G-protein coupled receptor kinase 2,GRK2
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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