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Anti-Human/Mouse/Rat Phospho-DDR1 (Tyr513) Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. DDR1 (Discoidin Domain Receptor Tyrosine Kinase 1) is a Protein Coding gene. Diseases associated with DDR1 include Pulmonary Fibrosis, Idiopathic and Breast Cancer. Among its related pathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DDR2.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01838
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human DDR1 around the phosphorylation site of Tyr513
Specificity Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot Q08345
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Formulation
Application WB,IHC-p,ELISA
Other Names CAK,CD 167,CD167,CD167 antigen-like family member A,CD167a,Cell adhesion kinase,DDR 1,DDR,DDR1,DDR1,Discoidin domain receptor,Discoidin domain receptor tyrosine kinase 1,Discoidin receptor tyrosine kinase,Discoidin receptor tyrosine kinase isoform a,EDDR 1,EDDR1,Epithelial discoidin domain receptor 1,Epithelial discoidin domain-containing receptor 1,Epithelial specific receptor kinase,HGK2,Mammarian carcinoma kinase 10,Mammary carcinoma kinase 10,MCK-10,MCK10,NEP,Neuroepithelial tyrosine kinase,Neurotrophic tyrosine kinase receptor type 4,NTRK 4,NTRK4,OTTHUMP00000029343,OTTHUMP00000029344,OTTHUMP00000029345,OTTHUMP00000029346,OTTHUMP00000029347,OTTHUMP00000164863,OTTHUMP00000164867,OTTHUMP00000222080,Protein-tyrosine kinase 3A,Protein-tyrosine kinase RTK-6,PTK 3,PTK 3A protein tyrosine kinase 3A,PTK3,PTK3A,Receptor tyrosine kinase NEP,RTK 6,RTK6,TRK E,TRKE,Tyrosine kinase DDR,Tyrosine kinase receptor E,Tyrosine-protein kinase CAK
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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