Home / Products / antibodies / Anti-Human/Mouse/Rat Phospho-AURKA (Thr288) Polyclonal Antibody

Anti-Human/Mouse/Rat Phospho-AURKA (Thr288) Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Contributes to the regulation of cell cycle progression. Required for normal mitosis. Associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. Phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Regulates KIF2A tubulin depolymerase activity (By similarity). Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01787
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human ARK-1 around the phosphorylation site of T288.
Specificity Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot O14965
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
Formulation
Application WB,IHC-p,ELISA
Other Names AIK,ARK-1,ARK1,AURA,Aurka,Aurora 2,Aurora A,Aurora kinase A,Aurora-related kinase 1,Aurora/IPL1 like kinase,Aurora/IPL1-related kinase 1,AURORA2,Breast tumor-amplified kinase,BTAK,hARK1,IAK,IPL1 related kinase,MGC34538,OTTHUMP00000031340,OTTHUMP00000031341,OTTHUMP00000031342,OTTHUMP00000031343,OTTHUMP00000031344,OTTHUMP00000031345,OTTHUMP00000166071,OTTHUMP00000166072,PPP1R47,Protein phosphatase 1,regulatory subunit 47,Serine/threonine kinase 15,Serine/threonine kinase 6,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A,STK15,STK6,STK6,STK7
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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