Anti-Human/Mouse/Rat PHLPP1 Polyclonal Antibody

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA10245
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human PHLPP1
Specificity In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 78% of tested tumors (at protein level). Ubiquitously expressed in non-cancerous tissues.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot O60346
Concentration 0.6 mg/mL
Dilution IHC 1:25-1:100
Formulation
Application IHC,ELISA
Other Names hSCOP,KIAA0606,PH domain and leucine rich repeat protein phosphatase,PH domain leucine rich repeat containing protein phosphatase,PH domain leucine rich repeat protein phosphatase,PH domain leucine-rich repeat-containing protein phosphatase 1,PH domain-containing family E member 1,PHLP1,PHLPP,Phlpp1,Pleckstrin homology domain containing family E (with leucine rich repeats) member 1,Pleckstrin homology domain containing family E protein 1,Pleckstrin homology domain-containing family E member 1,PLEKHE 1 protein,PLEKHE1,SCN circadian oscillatory protein,SCOP,Suprachiasmatic nucleus circadian oscillatory protein,Suprachiasmatic nucleus circadian protein
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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