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Anti-Human/Mouse/Rat p21 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA04227
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human p21 around the non-phosphorylation site of T145.
Specificity Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot P38936
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:50-1:200, ELISA 1:20000
Formulation
Application WB,IHC-p,ELISA
Other Names CAP20,CDK-interacting protein 1,CDKI,CDKN1,Cdkn1a,CDN1A,CIP1,Cyclin Dependent Kinase Inhibitor 1A,Cyclin-dependent kinase inhibitor 1,Cyclin-dependent kinase inhibitor 1A (P21),Cyclin-dependent kinase inhibitor 1A (p21,Cip1),DNA Synthesis Inhibitor,MDA-6,MDA6,Melanoma differentiation-associated protein 6,Melanoma differentiation-associated protein,p21,P21 protein,p21CIP1,p21Cip1/Waf1,p21WAF,PIC1,SDI1,SLC12A9,WAF1,Wild type p53 activated fragment 1 (WAF1),Wild type p53 activated fragment 1,Wildtype p53-activated fragment 1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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