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Anti-Human/Mouse/Rat OPTN Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA10295
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human OPTN
Specificity Present in acqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot Q96CV9
Concentration 0.3 mg/mL
Dilution IHC 1:25-1:100
Formulation
Application IHC,ELISA
Other Names 14.7K interacting protein,Ag9 C5,ALS12,E3 14.7K interacting protein,E3-14.7K-interacting protein,FIP 2,FIP-2,FIP2,Glaucoma 1 open angle E (adult onset),Glaucoma 1 open angle E,GLC1E,HIP 7,HIP-7,HIP7,Huntingtin interacting protein 7,Huntingtin interacting protein HYPL,Huntingtin interacting protein L,Huntingtin yeast partner L,Huntingtin-interacting protein 7,Huntingtin-interacting protein L,HYPL,Injury inducible protein I 55,NEMO related protein,NEMO-related protein,NRP,Optic neuropathy inducing protein,Optic neuropathy-inducing protein,Optineurin,OPTN,OPTN,TFIIIA IntP,TFIIIA-IntP,Transcription factor IIIA interacting protein,Transcription factor IIIA-interacting protein,Tumor necrosis factor alpha inducible cellular protein containing leucine zipper domains
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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