Anti-Human/Mouse/Rat/Monkey Insulin R Polyclonal Antibody

This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA04618
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human Insulin R around the non-phosphorylation site of Tyr1361.
Specificity Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas.
Isotype IgG
Reacitivity Human,Mouse,Rat,Monkey
Clone
Uniprot P06213
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:5000
Formulation
Application WB,ELISA
Other Names CD220,HHF5,human insulin receptor,Insr,INSR,Insulin receptor subunit beta,IR 1,IR,IR-1,IR1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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