Anti-Human/Mouse/Rat/Monkey EPOR Polyclonal Antibody

Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA03798
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human EpoR around the non-phosphorylation site of Tyr368.
Specificity Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early-stage erythroid progenitor cells.
Isotype IgG
Reacitivity Human,Mouse,Rat,Monkey
Clone
Uniprot P19235
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IF 1:100-1:300, ELISA 1:40000
Formulation
Application WB,IF,ELISA
Other Names EPO R,EPO-R,epor,EPOR,Erythropoietin receptor,Erythropoietin receptor precursor,MGC138358
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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