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Anti-Human/Mouse/Rat/Monkey CCKBR Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA02521
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the N-terminal region of human CCK-BR
Specificity Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC28 cell lines, not expressed in GLC19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
Isotype IgG
Reacitivity Human,Mouse,Rat,Monkey
Clone
Uniprot P32239
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:20000
Formulation
Application WB,ELISA
Other Names CCK B,CCK B receptor,CCK BR,CCK-B receptor,CCK-BR,CCK2 R,CCK2 receptor,CCK2-R,CCKB,CCKB receptor,CCKBR,CCKR Type B,CCKRB,Cholecystokinin 2 receptor,Cholecystokinin B receptor,Cholecystokinin-2 receptor,Cholecystokinin2 receptor,CholecystokininB receptor,GASR,GASR,Gastrin receptor,Gastrin/cholecystokinin type B receptor,Gastrincholecystokinin brain receptor
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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