Data Sheet | Click for Datasheet |
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Catalog Number | PA06956 |
Size | 100μl |
Host Type | Rabbit |
Immunogen | Recombinant protein of human LMNA |
Specificity | In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle celle (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress. |
Isotype | IgG |
Reacitivity | Human,Mouse,Rat |
Clone | |
Uniprot | P02545 |
Concentration | 0.6 mg/mL |
Dilution | WB 1:1000-1:5000, IHC 1:100-1:300 |
Formulation | Application | WB,IHC,ELISA |
Other Names | 70 kDa lamin,Cardiomyopathy dilated 1A (autosomal dominant),CDCD1,CDDC,CMD1A,CMT2B1,EMD2,FPL,FPLD,FPLD2,HGPS,IDC,Lamin A,Lamin A/C,Lamin A/C like 1,Lamin,Lamin C,Lamin-A/C,LDP1,LFP,LGMD1B,Limb girdle muscular dystrophy 1B (autosomal dominant),LMN 1,LMN A,LMN C,LMN1,LMNA,LMNA,LMNC,LMNL1,Prelamin A/C,PRO1,Renal carcinoma antigen NY REN 32,Renal carcinoma antigen NY-REN-32,Renal carcinoma antigen NYREN32 |
Storage | Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C. |
Postscript | For research use only, not for use in diagnostic procedures. |
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