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Anti-Human/Mouse/Rat LAT Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA04729
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human LAT around the non-phosphorylation site of Y200.
Specificity Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot O43561
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:20000
Formulation
Application WB,ELISA
Other Names 36 kDa phospho tyrosine adapter protein,36 kDa phospho-tyrosine adapter protein,36 kDa phospho-tyrosine adaptor protein,LAT 1,lat,LAT,LAT1,Linker for activation of T cells,Linker for activation of T cells family member 1,linker for activation of T cells,transmembrane adaptor,Linker for activation of T-cells family member 1,p36 38,p36-38,pp36
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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