Anti-Human/Mouse/Rat JAG1 Polyclonal Antibody

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA02445
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the Internal region of human Jagged1.
Specificity Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot P78504
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:10000-1:20000
Formulation
Application WB,IHC-p,IF,ELISA
Other Names AGS,AHD,AWS,CD 339,CD339,CD339 antigen,Headturner,hJ1,Htu,Jag 1,Jag1,JAG1,Jagged 1,Jagged1 (Alagille syndrome),Jagged1,JAGL1,MGC104644,OTTHUMP00000030278,Protein jagged-1,Ser 1,Ser1,Serrate 1,Slalom
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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